By George F. Vande Woude; George Klein (Eds.)
Advances in melanoma learn offers valuable info at the intriguing and fast-moving box of melanoma research. In this half A volume, outstanding and unique experiences offer an summary and synthesis of the most recent strategies and findings on the subject of Clusterin. Chapters contain the shifiting stability among CLU varieties in the course of tumor development, uclear CLU and the destiny of the mobile, and Oxidative rigidity in malignant development.
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Although we know much about Ca2þ fluxes, it is indicative that the definitive criteria which determine cell fate in response to Ca2þ are not known accurately. Possibly, Ca2þ concentration may vary in time, even may oscillate (Ca2þ influx from intracellular stores and subsequent extracellular Ca2þ entry) offering a room for somewhat diverse outcomes. Frequently, Ca2þ fluxes bring opposite consequences, such as cell proliferation versus differentiation, viability versus death, apoptosis versus necrosis.
2001). , 2007). Recently, novel information about the pathway of degradation of CLU has filled the void of knowledge about the basic metabolism of this protein in the cell. , 2009). In prostate cancer PC-3 cells CLU half-life is less than 2 h. , 2009). IV. CONCLUSIONS Many experimental evidences have demonstrated the existence of diverse CLU transcripts, making obsolete the idea that the human CLU gene produces a unique transcript. Concerning the mechanisms driving their synthesis, recent data show that many of the previous hypotheses, based on preliminary observations, are no longer true.
Skele, K. , Poulikakos, P. , Kuhajda, F. , and Testa, J. R. (2005). Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells. Oncogene 24(22), 3574–3582. Weis, B. , Foster, D. , and McGarry, J. D. (1994). Rat heart expresses two forms of mitochondrial carnitine palmitoyltransferase I. The minor component is identical to the liver enzyme. J. Biol. Chem. 269, 18712–18715. Zhang, S. , Ma, X. , Zheng, C. , Cao, X. , and Tian, W. X. (2008). Novel and potent inhibitors of fatty acid synthase derived from catechins and their inhibition on MCF-7 cell.